Vaccines may arrive in record time, but the virus has been faster

first_img How COVID-19 causes smell loss Seven Broad Institute physician researchers discuss their COVID-19 work and preparedness, the value of teamwork, and the fragility of life Related ‘Before a tsunami hits’ Agonizing over school-reopening plans? Think Marie Kondo Scientists have created candidate vaccines, which eventually could protect billions of people from COVID-19, with astonishing speed, compressing scientific efforts that usually take years into months. But the leader of a key drug trial said Tuesday that the blistering research pace has nonetheless been too slow to catch the coronavirus.“We are now five months into it, and a large-scale phase 3 trial launched yesterday, which is remarkable,” said Lindsey Baden, associate professor of medicine at Harvard Medical School (HMS). He also is a principal investigator of the first U.S. vaccine to enter such trials, some of which will happen at Harvard-affiliated Brigham and Women’s Hospital. “It is fast, but we need to be as fast as this virus is. … With four million infections, 150,000 deaths in this country alone, we have to move faster.”Baden is a principal investigator for the Brigham’s trial of a messenger RNA-based vaccine, whose promising early results in 45 volunteers prompted federal officials to approve it for large-scale trials. The trials of the vaccine from Moderna Inc. and the National Institute of Allergy and Infectious Diseases will involve 30,000 people at 89 locations around the country. Early results showed that the vaccine was well-tolerated by subjects receiving it — though there were passing side effects such as chills, headaches, and injection-site pain — and it induced an immune response in volunteers.The new trial will test that immune response on many more healthy subjects, seeing whether the vaccine protects from infection, and, as secondary goals, lessens severity of illness and reduces chances of death. The study will also probe the duration of any protection the vaccine provides.Baden and others involved in developing and testing other vaccine candidates said getting one approved for wide use is unlikely before early next year. Dan Barouch, the William Bosworth Castle Professor of Medicine and professor of immunology at HMS and Beth Israel Deaconess Medical Center, said a candidate vaccine could be ready for emergency authorization by late fall, but only if everything goes as well as possible between now and then. Barouch’s adenovirus-based vaccine is being developed and tested in conjunction with Johnson & Johnson.Trials of other promising vaccines are underway at the University of Oxford and in China.Baden and Barouch spoke at an online public briefing on vaccine progress by the Massachusetts Consortium on Pathogen Readiness, or MassCPR, an HMS-led, multi-institution collaboration aimed at better understanding the SARS-CoV-2 virus and developing treatments and vaccines to protect against COVID-19.The briefing included a discussion of how the human immune response works, of the challenges faced by high-risk communities, and of three major vaccine development efforts, along with a Q&A session.HMS Dean George Daley, who hosted the briefing, said the rapid development of several vaccine candidates — a process that typically takes three to nine years — was made possible by “countless unglamorous hours in the lab” over earlier years and was evidence of the importance of supporting basic research. Despite the speed at which progress has been made toward a COVID-19 vaccine, he pointed out that globally in just seven months, some 15 million people have been infected and 600,000 have died.“As the pandemic has caused grave human suffering, scientists have been working tirelessly to crack the biology and the behavior of the virus and develop treatments and vaccines,” Daley said. “They’ve done so with unprecedented speed and a true spirit of international cooperation and collaboration.”Bisola Ojikutu, assistant professor of medicine and of global health and social medicine at HMS, said trials should include significant numbers of members of minority groups and, whenever a vaccine is ready, distribution efforts should ensure that the communities most at risk aren’t in the background. Ojikutu said that hospitalizations, a measure of severe COVID-19, are 4.6 times higher among Latinx Americans than among whites, while those among Blacks and Indigenous people are 4.7 times and 5.3 times higher, respectively.Ojikutu said that efforts to tend to high-risk communities have hurdles to clear that include historical incidents of abuse, such as the Tuskegee syphilis study, in which 600 Black men with latent disease were observed without informed consent and never offered treatment when the disease became active. Other concerns include a vaccine’s safety, cost, and side effects.Ojikutu said a lack of trust is reflected in a recent Associated Press study that asked respondents whether they would agree to get a COVID vaccine. While 56 percent of white respondents said yes, only 37 percent of Latinx respondents did, and just 25 percent of Blacks. Ojikutu said experts are looking to successful public health campaigns for other conditions, such as the HIV Vaccine Trials Network, which increased minority participation in trials from 17 percent between 1988 and 2002 to 33 percent between 2002 and 2016.Strategies for recruiting minorities into trials include first acknowledging there is a trust problem, Ojikutu said, but also actively engaging the community, partnering with community health centers, holding virtual town halls and other informational outreach, and increasing the diversity of those working on the effort.“Quite honestly, diversity in clinical trials is both scientific common sense and promotes social justice,” Ojikutu said.The experts also discussed Barouch’s adenovirus vaccine, which uses an altered cold virus to present the immune system with SARS-CoV-2’s characteristic spike protein and generate an immune response. They also discussed another effort, supported by the Gates Foundation, that seeks to generate an immune response using a protein from part of the spike. That protein-based vaccine, according to Nicole Frahm of the Bill & Melinda Gates Medical Research Institute, would be cheaper to produce and distribute and so better able to reach disadvantaged countries and populations.Though much has been learned in the months since SARS-CoV-2 exploded globally, many important questions remain, participants said. One key question is how durable immunity is. Barouch said that trials in nonhuman primates showed that the immune response can be both robust and lasting, but evidence also has emerged in humans to cast doubt onto how lasting the immunity gained from infection will be. Questions remain about how long any immunity received from a vaccine will last, which is something the trials, coupled with the passage of time, should illuminate.“We believe that vaccines should proceed in parallel, since it is not yet clear which vaccine will be most protective and most deployable,” Barouch said. “There are 7 billion people in this world. Therefore we need multiple vaccines to be successful.” Report lists creative options amid pandemic, urges focus on essentials New study finds olfactory support cells, not neurons, are vulnerable to novel coronavirus infection The Daily Gazette Sign up for daily emails to get the latest Harvard news.last_img read more

Trump Administration Considers Market Interventions to Stop Retirements of Coal and Nuclear Plants

first_imgTrump Administration Considers Market Interventions to Stop Retirements of Coal and Nuclear Plants FacebookTwitterLinkedInEmailPrint分享Bloomberg:Trump administration officials are making plans to order grid operators to buy electricity from struggling coal and nuclear plants in an effort to extend their life, a move that could represent an unprecedented intervention into U.S. energy markets.The Energy Department would exercise emergency authority under a pair of federal laws to direct the operators to purchase electricity or electric generation capacity from at-risk facilities, according to a memo obtained by Bloomberg News. The agency also is making plans to establish a “Strategic Electric Generation Reserve” with the aim of promoting the national defense and maximizing domestic energy supplies.“Federal action is necessary to stop the further premature retirements of fuel-secure generation capacity,” says a 41-page draft memo circulated before a National Security Council meeting on the subject Friday.Although the memo describes a planned Energy Department directive, there was no indication whether President Donald Trump had signed off on the action nor when any order might be issued. The document, dated May 29 and distributed Thursday, is marked as a “draft,” which is “not for further distribution,” and could be used by administration officials to justify the intervention.Over dozens of pages, the memo makes the case for action, arguing that the decommissioning of power plants must be managed for national security reasons and that federal intervention is necessary before the U.S. reaches a tipping point in the loss of essential, secure electric generation resources. U.S. Defense Department installations are 99 percent dependent on the commercial power grid, one reason that electric system reliability is vitally important to national defense and homeland security, the memo asserts.For two years, the Energy Department would direct the purchase of power or electric generation capacity from a designated list of facilities “to forestall any future actions toward retirement, decommissioning or deactivation,” according to the memo. The proposed Energy Department directive also would tell some of those facilities to continue generating and delivering electric power according to their existing or recent contracts with utilities. The department’s intervention is meant to buy time for a two-year study of vulnerabilities in the American energy delivery system — from power plants that provide electricity to the natural gas pipelines that supply them. According to the memo, the planned action is a “prudent stop-gap measure” while the department addresses the nation’s “grid security challenges.”More: Trump Prepares Lifeline for Money-Losing Coal Power Plantslast_img read more

Pardew to change training regime

first_img The Magpies have put together a run of five successive victories, four of them in the Barclays Premier League, to completely change the complexion of their season. However, they have lost men along the way to injury, some of them on the training ground, and that is something the manager and his coaching staff will look to address as they attempt to strike a balance between achieving the highest possible fitness levels and the demands that places on the squad. Press Association Pardew told the Shields Gazette: “I met my staff and we are going to change one or two things. We are pushing these players to the limit. We’re trying to get the maximum we can out of them, and if you do that, you are going to lose players here and there. “The other players, you can tell, are really super-fit, and we’re strong. But we still need a few more bodies back. “As a group, we have to make sure we protect the players and give them the best possible chance to be at their maximum on a Saturday. “We’re pushing the players, and we’re going to get injuries. We’re pushing them because we want them to be fitter and stronger than everybody else, and so you’ve got a balance there. “We’ve just got to make sure we get that right, because we lost one or two that perhaps we shouldn’t have.” Captain Fabricio Coloccini is one of the men currently on the casualty list, although he picked up his calf problem in the 2-0 win at West Brom last time out and could be missing for several weeks. With Steven Taylor battling a similar injury, the Magpies recalled 20-year-old Remie Streete from his loan spell at Port Vale last week, although Taylor is hopeful of being fit for QPR’s visit to St James’ Park on Saturday. center_img Newcastle manager Alan Pardew is to ease the workload on his players after admitting they have been pushed to the limit.last_img read more

Backtracking on Darwinian Claims

first_img1.  Geraint Rees, “Vision: The Evolution of Change Detection,” Current Biology, Volume 18, Issue 1, 8 January 2008, Pages R40-R42.2.  For a similar claim by others, see the 01/07/2008 entry.3.  Rowe et al, “The oldest platypus and its bearing on divergence timing of the platypus and echidna clades,” Proceedings of the National Academy of Sciences USA, published online before print January 23, 2008, 10.1073/pnas.0706385105.4.  Gratten et al, “A Localized Negative Genetic Correlation Constrains Microevolution of Coat Color in Wild Sheep,” Science, 18 January 2008: Vol. 319. no. 5861, pp. 318-320, DOI: 10.1126/science.1151182.Translating Timothy Rowe’s jargon into colloquial English (blue quote in bullet #2 above), he said, “We’ll, I’ll be.  Shore looks like a platypus.  How come all its brethren evolved all over the place while he just sat there?  Musta been stuck in a Darwinian rut somehow.  Better tell my geneticist buddies their clocks are runnin’ super-fast and super-slow all at once.  The clocks musta e’en forced this little guy to evolve in slo-mo!  Whatever.  We KNOW dem bones is 120 million years old – that’s a fact, even if the clock is outta whack.”    Darwinism is the perfect playground for science fiction writers (that is, evolutionary biologists).  You never have to be right; you just have to look busy.  You can tell creative stories, then celebrate when they are overturned later.  The more complex the plot, the better.  You have no threat of criticism because your critics have been expelled and put behind a sound-proof barrier.  You get free checking for making reckless drafts on the bank of time (07/02/2007).  The peasants don’t revolt, because they have been hypnotized into thinking what you are working on is science.  Ah, the life of a Chaldean soothsayer.  It was bliss before Daniel showed up.(Visited 25 times, 1 visits today)FacebookTwitterPinterestSave分享0 Evolutionary theory evolves.  Since Darwinists no longer consider evolution progressive, it follows that evolutionary theory is also not necessarily progressing.  The following stories show evolutionary biologists backtracking on earlier claims.The pig is falling.  “Darwinian evolutionary theory proposes that the phenotype of a creature is an adaptation to the particular demands of the ecological situation in which it evolved,” wrote Geraint Rees [University College, London] in Current Biology.1  That’s what he intended to show in a report on a study suggesting humans are attracted more to animal motion than inanimate motion.2  He had to acknowledge, however, that a completely different, non-Darwinian interpretation is possible.  This led to him joking about why pigs don’t have wings:This suggests that the ability to detect change in animate objects represents a heritable trait that reflects implicit information about the external structure of the environment in which humans evolved, an intriguing possibility.  But while intuitively appealing, caution is required before accepting such an argument.  Jerry Fodor has recently argued that phenotypes do not always represent implicit information about the environment in which they evolved.  Instead, sometimes phenotypes simply reflect internal constraints on the functional organisation of that animal.  For example, Fodor suggests that the reason pigs do not have wings is less to do with the intrinsic structure of the environment that pigs inhabit, and more to do with the fundamentals of how the pig is constructed.  The lack of wings does not by itself carry any intrinsic information about the pig’s natural environment, and has not been selected against in the course of porcine history!In that case, there is no information about pig or human evolution to be gained from the study at all.  The findings about human propensity to pay attention to animal motion, instead, “provide important insights into the organisation of the human visual system,” he said, though he still held out hope that adding natural selection to the equation might inform the “discovery of the psychological architecture of human cognition.”Platypus granddaddy:  [email protected] examined the case of the ancient platypus (see 11/27/2007).  The bones of an apparent platypus 20 to 80 million years older than thought is causing confusion among evolutionary paleontologists.  Timothy Rowe, the discoverer, concluded “It looks like the monotremes may have had a really slow evolutionary history.”  Why the vast array of mammals underwent dramatic transformations in far less time, according to the Darwinian timeline, leaves a mystery why the platypus remained virtually unchanged.  “Rowe thinks the creatures probably didn’t need to evolve because their hunting abilities were so fine-tuned,” the report said.  This begs the question of why other predators with similarly fine-tuned hunting skills lack the evolutionary stasis, or why the platypus’s prey did not evolve so as not to be hunted so effectively.    The contrary explanation, that this was not a platypus fossil at all, but rather a remnant of a common ancestor of platypus and echidna, requires invoking convergent evolution.  A platypus-specific canal found in the skull would have had to evolve twice, once before the split, and once again after the split.  The illustration caption simply reads, “Older than we thought.”    The paper by Timothy Rowe et al in PNAS3 states the conundrum in scientific jargon:Morphology suggests that Teinolophos is a platypus in both phylogenetic and ecological aspects, and tends to contradict the popular view of rapid Cenozoic monotreme diversification.  Whereas the monotreme fossil record is still sparse and open to interpretation, the new data are consistent with much slower ecological, morphological, and taxonomic diversification rates for monotremes than in their sister taxon, the therian mammals.  This alternative view of a deep geological history for monotremes suggests that rate heterogeneities may have affected mammalian evolution in such a way as to defeat strict molecular clock models and to challenge even relaxed molecular clock models when applied to mammalian history at a deep temporal scale.Predators and unintended consequences:  The simple view is that predators kill prey, leading to prey that try to reproduce faster in greater numbers – a direct effect of evolutionary ecology.  A study with small fish called killifish that inhabit streams in Trinidad showed scientists a more complex view.  In addition to direct effects of predation, there are indirect effects that may be just as important: for instance, the availability of food after prey are reduced by the predators.  The whole community is restructured by reintroduction of predators.  “Since predator-induced indirect increases in resource availability are common in both terrestrial and aquatic ecosystems, the evolutionary consequences of these interactions are potentially a very important component of evolutionary change in nature,” said David Reznick, coauthor of the study.  “Moreover, biologists have observed evolutionary change occurring on short ecological timescales in nature, on the order of a few years to decades, suggesting that such interactions are contributing to overall ecosystem functioning and health.”  The changes he described, however, are microevolutionary changes to existing structures, not innovations.  If microevolutionary restructuring of ecological communities can be witnessed in mere decades, it adds to the conundrum of why the platypus remained unevolved for 100 million years.Black sheep in Darwin’s family:  Fitness is supposed to help you gain the upper hand in the race to survive, but the fitter black sheep of Scotland are dying out.  Why?  A study in Science4 found that fitness can work against you.  Dark coat color is correlated to larger body size, “which is heritable and positively correlated with fitness,” the research team said.  “This unexpected microevolutionary trend is explained by genetic linkage between the causal mutation underlying the color polymorphism and quantitative trait loci with antagonistic effects on size and fitness.”  The finding makes evolutionary inference more difficult.  “This result demonstrates the importance of understanding the genetic basis of fitness variation when making predictions about the microevolutionary consequences of selection.”  The article began, “The evolutionary changes that occur over a small number of generations in natural populations often run counter to what is expected on the basis of the heritability of traits and the selective forces acting upon them.”  When a scientist can’t expect what evolution will do, can Darwin really claim to have discovered a law of nature?Papa Neanderthal:  It seems the story of our relationship to Neanderthal Man is back and forth.  An article in the Australian News explains the problem: “For more than 150 years, a debate has raged over the origins of modern humans.  The main body of scientific thought says modern humans migrated from Africa and then overwhelmed their more primitive European counterparts, the heavy-browed Neanderthals, or inter-bred with them.  But growing credence is being given to the theory that homo sapiens [sic] evolved from the Neanderthals, who mysteriously died out some 28,000 years ago.”  So no one seems to know what the relationship was.  That did not stop the author from titling the report, “Bad weather helped evolution.”Tree trimming:  Darwin’s tree of life just lost a branch.  “The Tree of Life must be re-drawn, textbooks need to be changed, and the discovery may also have significant impact on the development of medicines,“ began an article in Science Daily.  New research by European biologists who compared 5000 genes in “the largest ever genetic comparison of higher life forms on the planet” now lumps brown algae and silica algae together.  “Previously, these species were thought to be completely unrelated,” the article states.  The article ended on a triumphal note that researchers are making progress toward understanding evolution.  Puzzles remain, however: “To make the picture a little less clear, one branch of chromalveolates is still in no man’s land,” claimed one researcher.Mammal disconnect:  The molecular and fossil stories about mammals don’t agree; see Geotimes for discussion.  Watch this space.  (That’s all there is to watch for now.)More than a chimp:  Be thankful for your DNA repair genes; they are unique.  An article in EurekAlert said, “researchers were surprised to find the acquisition of functional response for certain genes involved in DNA metabolism or repair to be mostly unique in humans.”  Some of the genes were shared with chimpanzees and rhesus monkeys; none were shared with mice.  The researchers wove their findings into an evolutionary story, but admitted, “the full implications of these evolutionary points remain far from clear….”The new buzz:  Remember the old story?  The one about the meteorites that killed the dinosaurs?  Scratch that.  It was bugs.  The new story can be found at The Guardian, which says, “Forget the meteorites – it was insects that did in the dinosaurs.”  This can be considered true till the next revision.  Hold the presses!  Maybe it was acid rain, reported EurekAlert.  But then again, that old Chicxulub meteor did make a mighty big splash, say the Longhorns.last_img read more

Altius invests in consumer website

first_img23 September 2008South African consumer affairs and complaints website getclosure! has announced that local black-owned investment company Altius Investment Holdings has acquired a stake in the business.The getclosure! complaint management portal allows consumers to submit their complaints online, delivering the complaint to the appropriate person in the supplier organisation and managing the complaint process until it is resolved.Funds from the investment will be used to promote the service and to fund enhancements to the getclosure! portal, including mobile access to the service.“Our experience is that most suppliers want to be told if their service has been sub-standard and welcome the opportunity to put it right,” getclosure! founder and director Ian Donovan said in a statement this week.“And we like the fact that a growing number of consumers are using our portal to compliment suppliers when they experience exceptional service.”Increased service performanceThe Ask Afrika Orange Index 2008, due for release in November, shows that service performance levels in South Africa have increased since last year from 58.2% to 61.6%.There is room for improvement however, with 65% a reasonable goal to aim for, according to Ask Afrika, adding that harnessing the reach of the internet to manage the complaints service process was one way to ensure effective outcomes and raise service levels in the country.“Many South Africans tolerate poor service without speaking up. By cleverly using the internet, getclosure! has made it quick, easy and cost effective to lodge a complaint,” said Society of Consumer Affairs Professionals South Africa chairperson Anne Sayers.“It then backs this up with an effective complaints resolution process that is not about naming and shaming the company involved.”Active usageSix months after the launch of the service, more than 500 suppliers actively use getclosure! to respond to customer complaints and compliments. Companies have the option to subscribe to the service to receive detailed reporting on complaints handled, customer feedback and the option to customise the landing pages.Subscribers to the service currently include FNB, Pick n Pay, Spar, Toyota, KFC and Cell C.“getclosure! is ideally placed to assist the business community and public sector to raise their service levels,” said Altius executive chairman Anwah Nagia. “The team is passionate about improving customer service and has built an exciting venture with a loyal community in a short space of time.”Altius is a South African-based investment company that facilitates community upliftment, development and empowerment through its investments, with a portfolio that spans agriculture, minerals and industrial waste management.The investment in getclosure! is Altius’ first foray into the digital world.SAinfo reporter Would you like to use this article in your publicationor on your website?See: Using SAinfo materiallast_img read more

Brand South Africa says farewell to Baby Jake

first_imgJohannesburg, Friday 13 December 2013 – Today South Africa puts to rest one of our national heroes and champions, Jacob Matlala affectingly known as ‘Baby Jake’ who passed away on Saturday morning following complications related to pneumonia at the age of 51.Speaking from Houghton Johannesburg, Brand South Africa CEO Miller Matola said, “Baby Jake was a national treasure, and not just for his indomitable spirit. It was his big heart that made South Africans proud of him the most which he demonstrated through his charity works.”“Baby Jake has played his part for our country. We are grateful for his efforts to profile South Africa and we will miss him but we will always cherish his work and his contribution to the South African brand,” concluded Mr Matola.Note to editorsAbout Brand South AfricaBrand South Africa is the official marketing agency of South Africa, with a mandate to build the country’s brand reputation, in order to improve its global competitiveness abroad. Its aim is also to build pride and patriotism among South Africans, in order to contribute to social cohesion and nation brand ambassadorship.Further resources from Brand South AfricaMedia are invited to visit for further resources which can be reproduced without any copyright infringement.  Kindly attribute to Brand South Africa.Follow Brand South [email protected]_SA ( us how you Play Your Part[email protected]#DoBestFor more information or to set up interviews, please contact Brand South Africa Communications:Arahna SinghTel: +27 11 712 5061 Mobile: +27 (0) 82 491 2332Email: [email protected]:   www.brandsouthafrica.comFikile MakhobaEmail: [email protected]: 082 404 4856Endslast_img read more

Negativity Has No Upside

first_img Get the Free eBook! Learn how to sell without a sales manager. Download my free eBook! You need to make sales. You need help now. We’ve got you covered. This eBook will help you Seize Your Sales Destiny, with or without a manager. Download Now Negativity has no upside. You do not achieve greater outcomes nor greater return on investing negative emotional energy in your problems, challenges, and inconveniences.Negativity creates a disempowered mindset. By reminding yourself how unhappy you are about a certain situation, you are changing your focus and your mental state. You negative mindset will cut you off from potentially positive choices. Your negative focus will blind you to opportunity.You make a negative situation even worse by investing your negative emotional state in it. You amplify the negativity. When something is already difficult or stressful, ratcheting up the negativity ratchets up already heightened emotional states. This is how relationships are destroyed.Being negative doesn’t help you to solve problems or challenges faster. Nor does it allow you to solve them more effectively. In fact, the opposite is true of negativity. It can be debilitating.Negativity doesn’t draw people to your cause. In fact, it can repel the very people whose help you need. Negativity attracts negative people. But to break through difficult challenges, you need the positive, can-do people who believe greater things are possible.Negativity doesn’t make a difficult conversation any easier. Quite the opposite. Negativity can make a difficult conversation crushingly painful. The emotional state and mindset of negativity makes it more likely that you turn a difficult situation into irreconcilable differences. Negativity is how relationships are damaged (or worse).In business and in life, you are going to have to deal with challenging situations and circumstances. You are going to have to deal with unpleasant and difficult people. You are going to fail from time to time, even when failure is not an option.Being negative about any or all of the above does nothing to change the situation or circumstance, nor does it allow you to deal with the circumstances more effectively. You don’t produce a better result by being negative.Making yourself feel bad does nothing to make you feel better. Deciding to feel powerless is not a recipe for being empowered and taking whatever necessary actions are required of you.Negativity is really fear. You are afraid that something bad will happen to you. You are afraid that you aren’t going to get what you want, that you aren’t capable of succeeding, or that you are going to be harmed in some way.There is no upside to negativity. But the upside for optimism and an empowered mindset is limitless.last_img read more

Erram still optimistic as loses pile up for Blackwater: ‘We still fought’

first_imgGlobe Business launches leading cloud-enabled and hardware-agnostic conferencing platform in PH And after being down 62-47 in the third, the Elite managed to go on a 21-8 run between the last two quarters to cut the lead to two, 70-68.Alaska, however, still held on to the lead after the Elite missed seven of its free throws in the fourth quarter.“We’re still on a positive spirit after the game,” said Erram. “Even though that was the performance we had, we still fought, we weren’t down big at the end.”ADVERTISEMENT Slow and steady hope for near-extinct Bangladesh tortoises Go: Search for ‘perfect, honest man’ to lead PNP still on PLAY LIST 01:31Go: Search for ‘perfect, honest man’ to lead PNP still on00:59Sports venues to be ready in time for SEA Games00:50Trending Articles01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City MOST READ Brace for potentially devastating typhoon approaching PH – NDRRMC John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding Read Next NEXT BLOCK ASIA 2.0 introduces GURUS AWARDS to recognize and reward industry influencers Don’t miss out on the latest news and information. center_img “Aside from the missed free throws, we are doing things that we don’t usually do,” said Erram in Filipino Saturday at Smart Araneta Coliseum. “We were shooting from spots we shouldn’t be even standing in.”“There were players who were driving who usually don’t drive to the basket.”FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSLillard, Anthony lead Blazers over ThunderSPORTSMalditas save PH from shutoutErram, who had a monster game of 14 points, 21 rebounds, and five blocks, became a glimmer of hope for Blackwater, but he wasn’t the lone bright spot for the Elite.Mac Belo and Mike Digregorio both finished with 15 points while Allein Maliksi and Roi Sumang had 10 points apiece. Kammuri turning to super typhoon less likely but possible — Pagasa Typhoon Kammuri accelerates, gains strength en route to PH LATEST STORIES 2 ‘newbie’ drug pushers fall in Lucena sting Blackwater’s JP Erram. PBA IMAGESBlackwater is on a funk right now, having lost three straight games to fall to the second-worst record in the standings in the PBA Philippine Cup.After the Elite lost 88-84 to Alaska to slide to 2-4, it’s obvious that they have not been doing things the right way and center JP Erram knows exactly what’s wrong.ADVERTISEMENT Hotshots buck Lee’s absence to beat KaTropa View commentslast_img read more

ROUND 6: Adrien Broner connects with quick uppercut

first_imgPrivate companies step in to help SEA Games hosting Pacquiao hits again but this time a jab in the middle of the ring.Broner throws a quick 1-2 combination that Pacquiao easily dodges.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine ‍football chiefSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool starsPacquiao then hits with his own 1-2 and follows it up with a couple of uppercuts.Broner closes the round with a quick uppercut. Oil plant explodes in Pampanga town Is Luis Manzano planning to propose to Jessy Mendiola? SEA Games hosting troubles anger Duterte LATEST STORIES Lacson backs proposal to elect president and vice president in tandem ROUND 5: Pacquiao still the aggressor in an uneventful round PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Manny Pacquiao, right, blocks a punch from Adrien Broner during WBA welterweight title boxing match Saturday, Jan. 19, 2019, in Las Vegas. APMANILA, Philippines—The pace of the action remains the same midway through the fight.Adrien Broner lets out a wild left and Paquiao hits him straight in the jaw that put the American to the corner.ADVERTISEMENT MOST READ Sports Related Videospowered by AdSparcRead Next LOOK: Joyce Pring goes public with engagement to Juancho Triviño TS Kammuri to enter PAR possibly a day after SEA Games opening SEA Games: Biñan football stadium stands out in preparedness, completion View comments Don’t miss out on the latest news and information. last_img read more